Totality of evidence of the effectiveness of repurposed therapies for COVID-19: Can we use real-world studies alongside randomized controlled trials?

In contrast, for the combination of hydroxychloroquine and azithromycin, the uncertainty in treatment effect estimates for RCT evidence alone (OR: 0.57, 95% CI = 0.19–1.73) was reduced with the combined RWS and RCT evidence but did not reach statistical significance (OR: 1.23, 95% CI = 0.94–1.61).

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