highly significantP<0.001
To validate this further, we transfected cells with ASO-MALAT1 and miR-30b mimic and observed a highly significant reduction in TLR8 ( P<0.001 ).
To validate this further, we transfected cells with ASO-MALAT1 and miR-30b mimic and observed a highly significant reduction in TLR8 ( P<0.001 ).
In contrast, the expression of M1Mφ markers iNOS (1.68 ± 0.87-fold), STAT1 (0.87 ± 0.52-fold), TNF-α (1.34 ± 0.49-fold), and ARG2 (1.81 ± 0.73-fold) showed a trend of upregulation in MALAT1 knockdown conditions, albeit the changes were not significant ( Figure 2A ; lower panel).