Polygenic risk score predicts risk of primary sclerosing cholangitis in inflammatory bowel disease.

BMJ Open Gastroenterol · 2023 · PMC10583098 · PMID 37832963

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a significant trendno p-value reported

Compared with IBD alone, IBD-PSC has a significantly higher PRS (−2.58 vs −2.82; p=0.004) and a significant trend of PSC risk (highest PSC risk 7.2% at the highest PRS quartile vs 3.0% at the lowest PRS quartile, P trend =0.03).

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