28 , 29 , 31 ICIs-related VTE occurrence was not independently associated with shorter PFS (HR 1.82, 95% CI 0.93-3.55, P = .08) ( Figure 3A ), and highly significant heterogeneity was shown between studies (Cochran's Q statistic, P < .0001, I 2 = 89%).
27 , 28 , 35 , 37 , 39 , 41 Among the studies that administered PD-1/PD-L1 inhibitor monotherapy, 3 were positive, meaning they observed an excellent correlation between ICIs-related VTE and poor OS, 29 , 40 , 42 and only 1 observed a shorter OS/PFS that did not reach statistical significance. 31 Of those that included anti-PD-1/PD-L1 and anti-CTLA4 combination therapy, 5 were positive 27 , 28 , 37 , 39 , 41 and only 1 was negative. 35 Data Review According to ITB Four of the 13 studies addressed the confounding impact of ITB on the results. 28 , 29 , 39 , 42 Of those, 3 of thes