Identifying potential DNA methylation markers for the detection of esophageal cancer in plasma.

Although the incidence rate and 5-year survival rate have showed a trend of gradual improvement in the last decade ( Li et al., 2021 ; He et al., 2022 ), the 5-year survival rate still remained below 30% ( He et al., 2020 ; Salta et al., 2020 ) likely because most EC cases were diagnosed and treated at the advanced stage ( Early Diagnosis and Treatment Group of the Chinese Medical Association Oncology Branch, 2022 ).

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