Chronic supplementation of a multi-ingredient herbal supplement increases speed of cognitive task performance alongside changes in the urinary metabolism of dopamine and the gut microbiome in cognitively intact older adults experiencing subjective memory decline: a randomized, placebo controlled, parallel groups investigation.

Here, only concomitant medications, participant age, waist-to-hip ratio (all trending towards significance at p = 0.05, 0.08, and 0.09, respectively) and sex of participant ( p = 0.01) were impactful.

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Location-action A trend toward significance was observed between treatments on day 1 ( F (1,127) = 3.77, p = 0.06) with the mean number of correctly remembered locations and actions significantly higher for the multi-ingredient herbal supplement (4.26) than placebo (3.56).

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Cognim app For the alert mood visual analogue scale, a trend towards significance ( F (13,1,287) = 1.69, p = 0.06) was explored further with a series of one-way ANOVAs; comparing each treatment at each post-dose assessment.

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Immediate word recall For immediate word recall correct, an overall trend towards significance for Treatment was observed ( F (1,750) = 3.61, p = 0.06) with the mean number of correct responses higher for the multi-ingredient herbal supplement (5.27) than placebo (5.02).

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