Influence of Genetic Polymorphisms on the Short-Term Response to Ranibizumab in Patients With Neovascular Age-Related Macular Degeneration.

Alternatively, two SNPs, rs7412 and rs4229358, which did not reach statistical significance in our study, were found to confer significantly better visual outcomes after anti-VEGF at short-term response. 47 , 48 Genetic variants of CRP have been shown to determine serum levels of this protein, particularly in response to inflammatory stimuli. 49 Several SNPs of CRP gene have been studied in relation to treatment response but related to photodynamic therapy (PDT). 50 Two variants related to this gene, rs2808635 and rs876538, did find an association between with response to PDT, but rs3093077 was not significative.

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