Multiomic prioritisation of risk genes for anorexia nervosa.

Investigation of prioritised AN associated genes We investigated two sets of prioritised genes in silico : (1) conditionally independent associations (TWAS/PWAS/spliceWAS) from marginally significant signals (FDR < 0.05) that are at least nominally jointly significant ( p < 0.05), and (2) genes in the finemapped 90% credible set with PIP > 0.4 and the absence of the null model in the credible set.

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From 313 significant TWAS signals, 97 genes had a conditionally independent association ( p Joint < 0.05) with AN as indicated by their nominally significant joint p value (online Supplementary Table S4).

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