Recently, the maternal-fetal immune response has become an important trend in RIF pathogenesis ( 40 ).
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Identification of MARK2, CCDC71, GATA2, and KLRC3 as candidate diagnostic genes and potential therapeutic targets for repeated implantation failure with antiphospholipid syndrome by integrated bioinformatics analysis and machine learning.
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Therefore, in RIF with APS, the imbalance of the maternal-fetal immunological microenvironment may be significant.