Vaccination with post-translational modified, homocitrullinated peptides induces CD8 T-cell responses that mediate antitumor immunity.

Although it did not reach statistical significance, it is evident from representative ELISpot images ( online supplemental figure 1 ) that Aldo 140-157Hcit and Cyk8 371-388Hcit responses were blocked in the presence of the CD4 blocking antibody but not in the presence of the CD8 blocking antibody confirming the presence of CD4-mediated responses to these peptides that is consistent with previous work ( figure 1C ). 17 Addition of either anti-CD8 or anti-CD4 antibody significantly reduced the immune response induced by Cyk8 112-132Hcit peptide suggesting the presence of both CD4 and CD8 epitopes within this sequence ( figure 1C ).

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