Serotonin Transporter mRNA Expression Is Reduced in the Peripheral Blood Mononuclear Cells of Subjects with Major Depression but Normal in Fibromyalgia.

Brain Sci · 2023 · PMC10605238 · PMID 37891852

Europe PMC DOI

hedged sentences

0.0610

closest p · 1.2× alpha

0.0800

boldest claim

The sentences

failed to reach statistical significancep = 0.061so close (0.05 < p ≤ 0.1)

Differences in SERT mRNA Expression between Groups before Treatment We observed a minor reduction in SERT mRNA expression in FM subjects relative to healthy subjects, but this potential difference failed to reach statistical significance ( p = 0.061) ( Figure 1 ).

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failed to achieve significancep = 0.08so close (0.05 < p ≤ 0.1)

There was a similar trend in the case of anxiety symptoms, which failed to achieve significance ( p = 0.08).

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barely significantno p-value reported

As for the increased DAT mRNA expression levels found in the FM + MDD subjects, this result was barely significant, suggesting that the observed effect is rather small.

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