Effects of Insulin on Proliferation, Apoptosis, and Ferroptosis in Primordial Germ Cells via PI3K-AKT-mTOR Signaling Pathway.

Genes (Basel) · 2023 · PMC10606282 · PMID 37895324

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showed a trendno p-value reported

The results showed the following ( Figure 5 A–C): the expression of GPX4 and SLC7A11, marker genes as negative regulators of cellular ferroptosis, showed a trend of upregulation (10 μg/mL) and then downregulation with the increase in insulin addition level during the culture of PGCs, while NOX4, a marker gene for positive regulation, showed the exact opposite trend ( p < 0.05).

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