Effects of C-Peptide on Dexamethasone-Induced In Vitro and In Vivo Models as a Potential Therapeutic Agent for Muscle Atrophy.

Foxo3a exhibited a decreasing trend in the DEX group compared to the CON group, and significantly decreased in the DEX+CP group compared to both the CON and DEX groups.

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However, in the group treated with 100 nM C-peptide this ameliorative effect was less pronounced, and the augmentation in the fusion index did not reach statistical significance compared to that in the DEX group ( Figure 1 A,B).

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