Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD.

Despite difficulties in detecting this protein via immunoblotting, we identified significant elevation of CHOP protein in the cortex of the rNLS8 mice (rNLS-Sal) of approximately 2.1-fold compared to the control (Ctrl-Sal), with a trend for a decrease in CHOP protein in rNLS-ASO mice (approximately 1.6-fold compared to rNLS-Sal mice), although this decrease did not reach statistical significance (Fig. 3D ).

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