First-line treatment with TKI plus brain radiotherapy versus TKI alone in EGFR-mutated non-small cell Lung cancer with brain metastases: a systematic review and meta-analysis.

BMC Cancer · 2023 · PMC10614414 · PMID 37904083

Europe PMC DOI

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0.2600

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0.2600

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did not reach statistical significanceP = 0.26not close (p > 0.1)

In our study, although upfront brain RT plus EGFR-TKIs was associated with significantly improved OS and iPFS in females but not in males, the difference in either OS or iPFS benefit between the two sexes did not reach statistical significance (HR of OS: 0.55 vs. 0.83, P = 0.26; HR of iPFS: 0.61 vs. 0.73, P = 0.31).

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