Mutation location of HCM-causing troponin T mutations defines the degree of myofilament dysfunction in human cardiomyocytes.

J Mol Cell Cardiol · 2021 · PMC10616699 · PMID 33148509

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a strong trendno p-value reported

Accordingly, PKA treatment of isolated cardiomyocytes decreases myofilament calcium sensitivity significantly in HCM 173 and with a strong trend in HCM 234 ( Fig. 6D – F , Table S5 ).

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