Chronic GCPII (glutamate-carboxypeptidase-II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques.

Alzheimers Dement (N Y) · 2023 · PMC10617575 · PMID 37915375

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closest p · 1.4× alpha

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a strong trendp = 0.07so close (0.05 < p ≤ 0.1)

Chronic 2‐MPPA reduced GCPII activity in dlPFC tissue The 2‐MPPA‐treated group showed a strong trend for reduced GCPII enzyme activity in dlPFC compared to the vehicle‐treated controls ( p = 0.07; Figure 4A ).

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