Insights into the conservation and diversification of the molecular functions of YTHDF proteins.

5) The combination of complementation experiments, domain swap-complementation and (in the case of ECT9) inhibition, taken together with the known requirement of ECT2’s m6A binding for functionality, implies that ALL of the Arabidopsis ECTs are capable of minding m6A transcripts – an important and highly significant finding. 6) The structural analysis of the disordered domains suggests that charge distribution and ability to form droplets may be playing an important role in determining ECT function as a te234 complimenter. 7) The improved phylogenetic tree is a useful addition to the field and now clearly shows the division of higher plant ECTs into the four sub groups.

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It is noteworthy, however, that there is a clear trend for non-complementors to be amongst the most highly divergent proteins in each group, as revealed by the length of the branches in the phylogenetic tree ( Fig 1B ).

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