Multiparity increases the risk of diabetes by impairing the proliferative capacity of pancreatic β cells.

The Matsuda index (insulin sensitivity) was ~10% lower in the parity-high group than in the parity-low group, and the insulinogenic index and disposition index (β cell function) tended to be lower in parity-high women, although these changes did not reach statistical significance (Fig. 5b , Supplementary Table 1 ).

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