Association of macular pigment optical density with retinal layer thicknesses in eyes with and without manifest primary open-angle glaucoma.

Siah et al reported a positive correlation between MPOD (0.5°) and peripapillary RNFL thickness in the inferior quadrant among patients with glaucoma, although this finding did not reach statistical significance. 5 Glaucoma preferentially affects the superior and inferior quadrants of the peripapillary RNFL, which makes the association of these regions with MPOD notable. 4 Peripapillary RNFL and GCC thinning are often detectable in early glaucoma before detectable visual field defects. 4 Thus, our findings relating MPOD to peripapillary RNFL and GCC thickness support the hypothesis that low MPOD may contribute to or serve as a biomarker of glaucoma.

also in 111,027 other papers