Altered plasma metabolite levels can be detected years before a glioma diagnosis.

JCI Insight · 2023 · PMC10619434 · PMID 37651185

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

borderline significantP = 0.06so close (0.05 < p ≤ 0.1)

However, in EPIC samples, only 1 of the 87 metabolites, fumarate, reached statistical significance ( P = 0.02) when focusing on samples collected up to 8 years to diagnosis, while cystine was borderline significant ( P = 0.06).

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did not reach statistical significanceno p-value reported

However, the predictions of nonglioblastoma within 2 years in NSHDS and EPIC did not reach statistical significance, likely due to small sample sizes.

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