Experimentally induced active and quiet sleep engage non-overlapping transcriptional programs in <i>Drosophila</i>.

Interestingly, four of these subunits were significantly upregulated in our optogenetic sleep dataset: nAchRα1, nAchRα3, nAchRα4, and nAchRα5 (with nAchRα6 and nAchRα7 approaching significance, Figure 7—source data 1 ).

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The establishment of such parallel sleep states in the fly is highly significant and identifying the physiological and molecular correlates of distinct sleep stages in the fly is of critical importance to the field.

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