Barely Significant
← all excerpts

Refphase: Multi-sample phasing reveals haplotype-specific copy number heterogeneity.

PLoS Comput Biol · 2023 · PMC10621967 · PMID 37871126

Europe PMCDOI
1
hedged sentence
0.0400
closest p · 0.8× alpha
0.0400
boldest claim

The sentences

moderately significantp = 0.04actually significant
Additionally, whilst Refphase’s ability to infer SCNA events at low tumour purities exceeds that of single-sample copy number calling methods ( Fig 4F ), even with Refphase, we observe a moderately significant association between the range of purities within a tumour (‘Tumour Purity Difference’) and the degree of SCNA subclonality (LME coefficient = 0.28, LME ANOVA p = 0.04, adjusted, S9B Fig ), indicating that tumour purity may interfere with the estimation of SCNA clonality.

also in 2,182 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.