Likewise, PCB treatment dose-dependently restricted the expression of cytokines mediating a proinflammatory Th1 phenotype in periarticular tissue homogenate as assessed by CBA: IFN-γ with a significant difference and a clear trend towards a reduction for TNF-α when the AIA + PCB 1 mg/kg was compared with the AIA + vehicle ( Figure 4B ).
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The effects of Phycocyanobilin on experimental arthritis involve the reduction in nociception and synovial neutrophil infiltration, inhibition of cytokine production, and modulation of the neuronal proteome.
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