Plasma NfL and CAF concentrations were 4.3% and 0.7% higher, respectively, in those with asymmetrical HGS compared to symmetrical HGS, however these differences did not reach statistical significance (27.65 pg/mL vs 26.52 pg/mL, p = 0.475 and 2.71 pg/mL vs 2.69 pg/mL, p = 0.823).
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Handgrip strength asymmetry as a new biomarker for sarcopenia and individual sarcopenia signatures.
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Therefore, although the between-group differences in NfL concentrations did not achieve significance in this study, the potential interplay between neural health, HGS asymmetry and circulating NfL is promising and warrants further investigation.