A randomized, double-blind, placebo-controlled, parallel group study on the effects of a cathepsin S inhibitor in primary Sjögren's syndrome.

Rheumatology (Oxford) · 2023 · PMC10629789 · PMID 36864622

Europe PMC DOI

hedged sentences

0.1251

closest p · 2.5× alpha

0.1251

boldest claim

The sentences

did not reach statistical significanceP = 0.1251not close (p > 0.1)

The adjusted mean concentration (g/l) of IgG at baseline between anti-SSB-negative (13.61) and -positive patients (15.78) did not reach statistical significance ( P = 0.1251).

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a slight trendno p-value reported

At week 12, the RO5459072 arm showed a slight trend towards improvement over the placebo arm with respect to mechanically stimulated salivary flow.

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