The area of α-SMA staining in each of these groups was then estimated, which showed a trend towards being larger in the low score group ( Fig. 1F ). mRNA expression datasets of fibroblasts extracted from fresh surgical specimens of colorectal carcinoma (CAF group) and normal colonic mucosa (normal colonic fibroblasts, NCF group) were obtained using NCBI GEO database (accession no.
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The apelin‑apelin receptor signaling pathway in fibroblasts is involved in tumor growth via p53 expression of cancer cells.
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