Protective role of CXCR7 activation in neonatal hyperoxia-induced systemic vascular remodeling and cardiovascular dysfunction in juvenile rats.

Whereas hyperoxia-exposed placebo (PL) treated rats had increased aortic stiffness as evidenced by increased PWV, the administration of a specific CXCR7 agonist, TC14012 showed a trend to decreasing hyperoxia-induced aortic stiffness to room air levels but this was not statistically significant (Fig. 2 A).

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