Human papillomavirus vaccine impact on invasive cervical cancer in Japan: Preliminary results from cancer statistics and the MINT study.

Cancer Sci · 2023 · PMC10637081 · PMID 37688310

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.2600

boldest claim

The sentences

a decreasing trendp < 0.001actually significant

7 The incidence of ICC among Japanese women aged 20–29 years significantly increased during 1975–2011 (APC 5.9, 95% confidence interval [95%CI] 5.6 to 6.1, p < 0.001), in line with previous reports, 13 , 14 , 15 but converted to a decreasing trend from 8.0 to 2.8 (reduction rate 65.0%) during 2011–2020 (APC −13.5, 95%CI −11.9 to −14.5, p < 0.001).

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marginally significantp = 0.05actually significant

However, when the analysis was confined to 2017–2022 data, HPV16/18 prevalence decreased from 90.5% to 64.7% among young women aged 20–29 years, and this progressive decrease was marginally significant ( p = 0.05; Cochran‐Armitage trend test). 4.

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did not reach statistical significancep = 0.26not close (p > 0.1)

The difference in these linear trends did not reach statistical significance ( p = 0.26).

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