Insulin-like growth factor binding protein-3 mediates hyperosmolar stress-induced mitophagy through the mechanistic target of rapamycin.

The mechanism by which IGFBP-3 mediates these mitochondrial effects is still unclear and may be significant for the development of novel therapies for certain mitochondrial diseases.

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While cells cultured in 450 mOsm showed a trend towards an increase in LC3-II, this effect was small and only significant at the higher test concentration ( Fig. 1 K , p = 0.041 in 500 mOsm).

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