However, when adjusting for the top SNP (rs6914651) in the regression model, neither HLA-DPB1*03:01 or HLA-DPB1*04:01 were nominally significant, suggesting that it might not be a specific HLA-DPB1 allele that affects AU risk (supplementary Data 7 ).
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The sentences
Three additional genes exhibited borderline significant p values and represented results from extremely rare gene-burden masks that consider only variants appearing once in each cohort (singletons).