Mining cancer genomes for change-of-metabolic-function mutations.

Commun Biol · 2023 · PMC10638295 · PMID 37950065

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highly significantno p-value reported

Thus, unbiased metabolite profiling revealed highly significant changes in xanthosine and FMN associated with the expression of a candidate COMF mutation in OGDHL.

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near-significantno p-value reported

While the direct substrates of mutant ODGHL (ɑ-ketoglutarate and succinyl-CoA) were not detected within the screen, we did detect near-significant changes in several metabolites that are closely related to wild type OGDHL functions as shown in the Fig. 3c schematic.

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