Transcriptomic analysis reveals that RasGEF1b deletion alters basal and LPS-induced expression of genes involved in chemotaxis and cytokine responses in macrophages.

Nine genes ( Ccl7, Ccl8, Ccl12, Vcam1 , Ch25h , Serpinb2 , Cd38 , Slfn4 , and Ptchd1 ) were confirmed to be significantly down-regulated, compared to wild-type, while F13a1 , Ccl2, and Selp1 exhibited a comparable trend of down-regulation as in the RNA-seq data that did not reach statistical significance (Fig. 4 a,b; Supplementary Fig.

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