Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor.

In contrast, Gα s KO cells showed a trend of higher GRK6 recruitment to β2AR compared with wildtype cells and reversion of this effect after re-expressing Gα s ( Fig. 4 A , bottom panels ).

also in 53,322 other papers