A cross-disorder study to identify causal relationships, shared genetic variants, and genes across 21 digestive disorders.

iScience · 2023 · PMC10641500 · PMID 37965154

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Genetic causal relationships across 21 digestive disorders Among 91 pairs of the 14 disorders with significant heritability, 64 pairs showed positive genetic correlation with Bonferroni correction (p ≤ 0.05/91), and the other 18 pairs had nominally significant genetic correlations (p ≤ 0.05), indicating considerable genetic basis of complex relationships among these disorders ( Figure 3 A; Table S5 ).

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