Although the differences did not reach statistical significance, fatigue-induced decreasing trends in pyruvic acid and citric acid from resting to fatigued state observed in Sham rats (pyruvic acid: 0.7-fold; citric acid: 0.7-fold) were not observed in Nx rats (pyruvic acid: 1.0-fold: citric acid: 1.1-fold).
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Skeletal muscle endurance declines with impaired mitochondrial respiration and inadequate supply of acetyl-CoA during muscle fatigue in 5/6 nephrectomized rats.
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