SMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy.

Commun Biol · 2023 · PMC10643621 · PMID 37957344

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Notably, we confirmed significantly decreased NE levels in the spinal cord of SMNΔ7 mice at P6 and showed a trend towards reduction of this neurotransmitter levels at P3, compared to the age-matched WT littermates (genotype, F (1,49) = 12.31, p = 0.0010; age×genotype, F (2,49) = 2.923, p = 0.0632; P3, p = 0.0938; P6, p = 0.0003; Fig. 4g ; Supplementary Table 4 ).

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