IL-7 receptor signaling drives human B-cell progenitor differentiation and expansion.

Using the LMPP cluster as the starting point, the early BCP clusters showed a trend toward earlier pseudotime values in the patients ( Figure 3 E), reflecting the aberrant differentiation that we observed ex vivo and in vitro ( Figures 1 C-E and 2 B-E) and suggesting impaired progression toward the B-lymphoid fate.

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