Treatment with recombinant Sirt1 rewires the cardiac lipidome and rescues diabetes-related metabolic cardiomyopathy.

Cardiovasc Diabetol · 2023 · PMC10644415 · PMID 37957697

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showed a trendno p-value reported

However, in qualitative terms, rSirt1 treatment showed a trend towards the reduction of TAGs containing only SFAs and the increase of TAGs containing docosahexaenoic acid [ 45 ], the latter being associated with cardioprotective effects by direct modulation of autophagy in cardiomyocytes [ 46 ].

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