Activin type I receptor polymorphisms and body composition in older individuals with sarcopenia-Analyses from the LACE randomised controlled trial.

While mean adjusted leg fat mass remained higher in AA/AG males than GG males this did not reach statistical significance ( Table 3 ). rs2854464 Analysis of the rs2854464 allele showed a similar pattern to that described for rs10783486 both with no associations with total muscle mass or limb muscle mass ( Table 4 and S2 Fig ) but with the males carrying the minor allele (rs2854464 AG/GG) being taller than males homozygous for the major allele (rs2854464 AG/GG: 174±7 cm vs AA: 170±5cm, p = 0.017, Fig 4A ).

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