Gluten restriction in irritable bowel syndrome, yes or no?: a GRADE-assessed systematic review and meta-analysis.

Front Nutr · 2023 · PMC10646307 · PMID 38024368

Europe PMC DOI

hedged sentences

0.2100

closest p · 4.2× alpha

0.2100

boldest claim

The sentences

showed a trendp = 0.210not close (p > 0.1)

Although the pooled data from eight studies showed a trend of reduction of abdominal pain, but this significance was lost for both subgroups, without between subgroup heterogeneity ( p = 0.210).

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a slight trendno p-value reported

In contrast to gluten-containing diet, GFD was unable to reduce overall symptoms (SMD − 0.31; 95% CI −0.92, 0.31), bloating (SMD −0.37; 95% CI −1.03, 0.30), and quality of life (SMD −0.12, 95% CI −0.64, 0.39); but had a slight trend to reduce abdominal pain (SMD –0.68; 95% CI −1.36, −0.00).

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