The role of admixture in the rare variant contribution to inflammatory bowel disease.

Power to establish whether a variant is a risk factor or not is low as there were only 1774 AA cases and accordingly only R161H in SDF2L1 was even nominally significant ( p = 0.005) in AA, yet all 8 risk alleles with European MAF > 0.01 are concordant in their observed direction of effect in AA and EA (contrast the heights of the dark and lighter-blue shades for AA, or dark and lighter reds for the two EA cohorts in Fig. 1 ).

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A corollary of these results is that there is a highly significant correlation between the proportion of the genome, at the 13 chromosomes, derived from European ancestry, and risk of CD.

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