Although in some tumor samples the methylation level increased, the overall median methylation demonstrated a decreasing trend in the majority of tumors ( Figure 1 C).
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Although the promoter methylation values become more spread in cancer, we observed an evident trend of hypomethylation in tumors compared to normal specimens ( Figure 1 C).
Although this effect did not reach statistical significance in ZNF714-OE cells in the transwell assay ( Figure 3 D), the cells did show a trend of higher migration and invasion.