Protein Disulfide Isomerase Family A Member 3 Knockout Abrogate Effects of Vitamin D on Cellular Respiration and Glycolysis in Squamous Cell Carcinoma.

In general, treatment of A431WT cells with 1,25(OH) 2 D 3 resulted in a decrease in glycolysis ( Figure 4 B), glycolytic capacity ( Figure 4 C), glycolytic reserve ( Figure 4 D), and non-glycolytic acidification ( Figure 4 E), but the results were marginally statistically significant.

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Overall, it was shown that deletion of PDIA3 enhances all parameters of oxidative phosphorylation; however, despite the clear trends, some results did not reach statistical significance.

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