Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production.

Arthritis Res Ther · 2005 · PMC1065327 · PMID 15743480

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did not reach statistical significanceno p-value reported

Although a decrease in MMP-13 was noted with the MEK1/2 kinase inhibitor PD98059 at the concentration tested, it did not reach statistical significance.

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