Renal gene expression of Tie2 and Tie1 was also higher in females compared to males, however, both did not reach statistical significance (both p = 0.09, Fig 3C and 3D ), whereas renal VE-PTP gene expression did not differ between female and male mice ( Fig 3E ).
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Female sex protects against renal edema, but not lung edema, in mice with partial deletion of the endothelial barrier regulator Tie2 compared to male sex.
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