Dengue virus 4/2 envelope domain chimeric virus panel maps type-specific responses against dengue serotype 2.

While convalescent sera from natural infection targeted EDI at a similar frequency to that of human challenge studies (37.5% vs 38.4%), they had lower titers that did not reach statistical significance ( Fig. 7B ; Table S5 ) (W = 45, P = 0.61).

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