Hepatic Activin E mediates liver-adipose inter-organ communication, suppressing adipose lipolysis in response to elevated serum fatty acids.

Consistent with an effect of Activin E on lipolysis, liver specific overexpression of Inhbe reduced fasting circulating NEFA by over 20 % relative to EV AAV treated controls, although this difference failed to reach statistical significance ( Figure 3 L).

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