Barely Significant
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CD8<sup>+</sup> chimeric antigen receptor T cells manufactured in absence of CD4<sup>+</sup> cells exhibit hypofunctional phenotype.

J Immunother Cancer · 2023 · PMC10660840 · PMID 38251688

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did not reach statistical significanceno p-value reported
The hCD19-BB-z and 1.5.3-NQ-28-z transduced cells similarly exhibited lower levels of cytokine secretion (though TNF-α for hCD19-BB-z and IFN-γ for 1.5.3-NQ-28-z did not reach statistical significance) and less proliferation in CD8 + CAR T cells cultured in the absence of CD4 + cells ( online supplemental figures 11,12E,G ).

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