Pithoviruses Are Invaded by Repeats That Contribute to Their Evolution and Divergence from Cedratviruses.

From that, we observed a significant trend (Cochran–Armitage test P value = 2.6 × 10 −3 ) whereby newly acquired genes appeared more frequent than ancestral genes in these regions ( Fig. 6A ).

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We also searched for the Pithovirus sibericum divergent MCP gene (pv_460) in the assembled metagenomic contigs using TBLASTN and found a highly significant match ( E value < 10 −22 ) in 9 out of the 10 analyzed data sets.

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